IN VITRO SUSCEPTIBILITY OF ISOLATED SHIGELLA FLEXNERI AND SHIGELLA DYSENTERIAE TO THE ETHANOLIC EXTRACTS OF TRACHYSPERMUM AMMI AND PEGANUM HARMALA
By: Ibrahim Siddig Hamid
.
Contributor(s): Eltayeb, Ikram Mohamed.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(1).Description: 103-106p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
This study represents the first attempt to investigate the antimicrobial activity of
Peganum
harmala
,
and
Trachyspermum
ammi
seeds
extract
against the isolated bacillary dysentery
-causing
microorganisms.
Method
s:
T.
ammi
and
P.
harmala
were extracted by 96% ethanol using Soxhlet apparatus. The extracts were screened for their phytochemical
constituents. Their antimicrobial activity against
the isolated
dysentery
-causing
microorganisms was evaluated using the agar diffusion method.
Result
s:
The antimicrobial activity result showed that, the two isolated bacteria,
Shigella flexneri
,
and
Shigella dysenteriae
were found to be
sensitive to the extract of
T.
ammi
seed with
inhibition zones up to 2
5 mm
, compared to the inhibition zone of 2
0 mm
produced by Gentamycin
standard drug
, this is mainly due to the presence of the different phytochemical in the extract such as tannin, flavonoids, terpenoids whi
ch are well
known for th
eir antimicrobial effects
. The two isolated bacteria were
found to be insensitive (zero mm) to
P.
harmala
extract,
Amoxicillin
, and
Amoclan (Amoxicillin
+clavulanic acid) standard
drugs,
this is due to the fact that, the phytochemicals constituents of
P.
harmala
possess
the
antagonistic effect to
each
other’s
. Addition t
o;
these bacteria became resistant to both Amoxicillin and Amoclan.
Conclusio
n:
From the results it concludes,
T.
ammi
seeds extract had a considerable level of antimicrobial activity against bacillary dysentery
-
causing
microorganisms resistant to Amoxicillin and Amoxicillin
+clavulanic acid drugs.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020944 |
Objective:
This study represents the first attempt to investigate the antimicrobial activity of
Peganum
harmala
,
and
Trachyspermum
ammi
seeds
extract
against the isolated bacillary dysentery
-causing
microorganisms.
Method
s:
T.
ammi
and
P.
harmala
were extracted by 96% ethanol using Soxhlet apparatus. The extracts were screened for their phytochemical
constituents. Their antimicrobial activity against
the isolated
dysentery
-causing
microorganisms was evaluated using the agar diffusion method.
Result
s:
The antimicrobial activity result showed that, the two isolated bacteria,
Shigella flexneri
,
and
Shigella dysenteriae
were found to be
sensitive to the extract of
T.
ammi
seed with
inhibition zones up to 2
5 mm
, compared to the inhibition zone of 2
0 mm
produced by Gentamycin
standard drug
, this is mainly due to the presence of the different phytochemical in the extract such as tannin, flavonoids, terpenoids whi
ch are well
known for th
eir antimicrobial effects
. The two isolated bacteria were
found to be insensitive (zero mm) to
P.
harmala
extract,
Amoxicillin
, and
Amoclan (Amoxicillin
+clavulanic acid) standard
drugs,
this is due to the fact that, the phytochemicals constituents of
P.
harmala
possess
the
antagonistic effect to
each
other’s
. Addition t
o;
these bacteria became resistant to both Amoxicillin and Amoclan.
Conclusio
n:
From the results it concludes,
T.
ammi
seeds extract had a considerable level of antimicrobial activity against bacillary dysentery
-
causing
microorganisms resistant to Amoxicillin and Amoxicillin
+clavulanic acid drugs.
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